Although SAM-e and glucosamine are not prescription products in the United States, both have been extensively studied around the world. The table below outlines a selection of studies on each agent. Click on the title of the study to view a more complete summary; click on the link in the product column to read more about research in that area.

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Product Year Study Author Journal Length
Glucosamine 2001 Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial Reginster JY Lancet 36 mo
Glucosamine 1992 Clinical research in osteoarthritis: design and results of short-term and long-term trials with disease-modifying drugs Rovati LC Int J Tissue React 4-6 wks
Glucosamine 1998 Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis Qiu GX Azneimittel-
forschung		 4 wks
Glucosamine 1994 Glucosamine sulfate in osteoarthritis of the knee Noack W Osteoarthritis Cartilage 4 wks
Glucosamine 1994 Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee Muller-Fassbender H Osteoarthritis Cartilage 4 wks
SAM-e 1987 Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease Caruso I Am J Med 30 d
SAM-e 1987 Double-blind controlled clinical trial of oral S-adenosylmethionine versus piroxicam in knee osteoarthritis Maccagno A Am J Med 84 d
SAM-e 1987 A new medical approach to the treatment of osteoarthritis. Report of an open phase IV study with ademetionine (Gumbaral) Berger R Am J Med 8 wks
SAM-e 1987 A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis Konig B Am J Med 24 mo
SAM-e 1987 Double-blind clinical trial of S-adenosylmethionine versus ibuprofen in the treatment of osteoarthritis Muller-Fassbender H Am J Med 4 wks

For a more comprehensive, printable list of references, please click here.



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