Patients with bipolar disorder should take any SAM-e product only under a practitioner’s care, since there have been reports of mood swings in bipolar patients not taking mood stabilizers. Patients taking prescription antidepressant medications should consult a healthcare provider before using this product. People who are on or have recently taken MAO inhibitors should not take any product containing SAM-e except under supervision.

People with allergies to shellfish or diabetes should consult their physicians before taking any product containing glucosamine.

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