In a nutshell, SAM-e (short for s-adenosylmethionine) is formed from the essential amino acid methionine and adenosine triphosphate (ATP). SAM-e can be found in
every living cell, and is a methyl donor in over 100 different reactions catalyzed by
methyltransferase enzymes.
It’s chemical formulation is shown below.
To support joint health, SAM-e supports sulfate groups’ incorporation into
proteoglycans, which help maintain cartilage and protect joints. Cysteine and
glutathione (GSH) are by-products of this process and have potent reducing
properties. Additionally, SAM-e’s action in the aminopropylation pathway induces
polyamine production, which is essential to cell and tissue growth, and may protect
proteoglycans and reduce inflammation and pain.
Please click to see a representation of SAM-e’s mechanism of action.
